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Discusses the classic biophysical work of Hodgkin and Huxley, weaves a description of the known ionic channels together with their biological functions, and then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, molecular diversity, and channel evolution. Includes new chapters on fast chemical synapses, modulation through G protein-coupled receptors and second messenger systems, molecular cloning, site-directed mutagenesis, and cell biology. Annotation copyright Book News, Inc. Portland, Or.